Book Abstract
Gastrointestinal Immunology delivers a holistic and forward-looking picture of gut immune dynamics?from foundational barrier and cellular biology to translational innovation in diagnostics, nutrition, and immunotherapy. The volume serves as a vital resource for immunologists, gastroenterologists, and translational scientists aiming to harness gut immunity for personalized disease prevention and therapy.
Gastrointestinal (GI) immunology lies at the crossroads of mucosal defense, microbial symbiosis, and systemic immunity. Gastrointestinal Immunology: Recent Advances and Emerging Concepts presents a state-of-the-art overview of dynamic interactions between the gut barrier, immune cells, and microbiota, while highlighting how these mechanisms influence disease and therapy.
The intestinal mucosal barrier?comprising epithelial cells, tight junctions, mucus, and IgA?is essential for distinguishing between harmless and harmful antigens; its breakdown contributes to a range of GI diseases including IBD, IBS, metabolic syndrome, and NAFLD.
Gut-associated lymphoid tissue (GALT), including Peyer?s patches and M cells, orchestrates antigen sampling and tolerance, with vitamin?A?derived retinoic acid inducing key homing receptors (?4?7, CCR9) on lymphocytes.
